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ABSTRACT
Mercury chloride (HgCl2) acts as a bioaccumulator capable of causing numerous neurological and physiological changes in organisms in a negative way. However, naringenin has been considered a very effective antioxidant compound in the treatment of neurodegenerative diseases, as it can neutralize radicals capable of damaging neuronal cells. In this context, this study aimed to evaluate naringenin as a neoprotective agent against the damage induced by HgCl2 in Drosophila melanogaster. To assess the antioxidant action of Naringenin, in concentrations: After the survival study, Negative geotaxis assay and open field assay was carried out. Group 1 control, Group 2 Mercury chloride -> 1mg/g,Group 3- Naringenin (conc. that produces the least mortality),Group 4- Naringenin (conc. that produces the least mortality)+ 1mg/g mercury chloride. Biochemical assays were carried out such as; SOD,GST,MDA,CAT and AChE .The group treated with HgCl2 alone had a high mortality rate, while in combination with different concentrations of Naringenin, it had a moderate reduction in the number of deaths, as well as in the negative geotaxis data in which the Naringenin had a positive effect. The results demonstrate that mercury chloride can cause oxidative stress in Drosophila melanogaster. In conclusion, the results suggest that Naringenin has antioxidant and protective effects against the damage caused by HgCl2.
