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ABSTRACT
Bisphenol A (BPA) is a industrial chemical used in the synthesis of polycarbonate, epoxy resins and plastics. It is associated with neurological and behavioural problems. Rutin, a flavonoid is an essential anti-oxidant. It plays an important role in protecting cells from oxidative damages. The anti-oxidant capacity results from its ability to donate electrons to reactive oxygen species and neutralize them. The fruit flies were divided into six groups with each treatment tube containing 30 flies. Group c: control flies fed on 10g of basal diet. Group A: flies fed on basal diet + 40mM of BPA. Group B: basal diet + 0.25mg of Rutin. Group D: basal diet + 0.50mg of Rutin Group F: basal diet + 0.25mg of Rutin+40mM of BPA. Group G: basal diet + 0.50mg of Rutin +40mM of BPA. The experimental period lasted for 6 weeks. In the results, data for negative geotaxis was represented on a bar chart while for survival rate was on a graph curve. Data for malondialdehyde(MDA) and glutathione transferase(GST) were represented as mean ± standard error of mean (SEM). Values obtained were examined using analysis of variance (ANOVA), and the least significance difference (LSD) analysis, to evaluate the differences among groups and for multiple comparisons among different groups. P<0.05 was the level of significance used. SPSS/PC software was used in all calculations. The result showed that there was a decrease in the survival rate in flies treated with BPA only while flies coadmistered with BPA and Rutin had improved survival rate when compared with those treated with BPA only. Flies treated with BPA had a decrease climbing time (negative geotaxis) compared to control (indicating locomotor deficit) while coadministration of Rutin and BPA improved the climbing time when compared to the BPA treated group only. There was a significant increase in MDA (indicative of oxidative stress) in flies treated with BPA when compared to control. In flies coadministered with Rutin and BPA, there was a significant reduction in MDA when compared to BPA treated flies only. We also found a significant reduction in GST activity in flies treated with BPAonly when compared to control. Flies in which Rutin was coadministered with BPA, showed a significant improvement in GST activity when compared with BPA treated flies only.
