NEPHROTOXICITY OF MONOSODIUM GLUTHAMATE EXPOSURE IN ADULT WISTAR RATS: PROTECTIVE POTENTIAL OF VITAMIN E

ABSTRACT

The study aimed to explore whether vitamin E could mitigate the toxcity induced by monosodium glutamate(MSG) in adult wistar rat. Twenty rats were divided into four groups; a control group, a group receiving only MSG at a dosage of 200mg/kg body weight for 28days, a group receiving both MSG and Vitamin E at a dosage of 100 IU/kg body weight following MSG treatment, and a group receiving only vitamin E at the same dosage for the same duration. The histology examination revealed that co-administration of vitamin E with MSG effectively protected kidneys against MSG-induced damage. This suggests that vitamin E has a protective role against the renal toxicity caused by MSG. In summary, the study provides the evidence supporting the histological protective effect of vitamin E against MSG-induced kidney damage in rats.