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ABSTRACT
Kidney damage and nephrotoxicity are significant health concerns with limited treatment options. Phyllanthus amarus, a traditional medicinal plant, is reputed for its potential nephroprotective properties. This study investigates the nephroprotective effect of Ethanol extract of Phyllanthus amarus (EEPA) leaves on Carbon tetrachloride-induced Male Albino Wistar rats. Male Wistar rats(n=24) were divided into 5 groups: normal control, Carbon tetrachloride control, silymarin control, EEPA (200mg/kg.b.w) and EEPA (400mg/kg.b.w) groups. Kidney damage was induced through oral administration of Carbon tetrachloride at a dose of 3mL/kg.b.w. The rats were treated using Silymarin, (a known antibiotics) and EEPA ( 200mg/kg.b.w and 400mg/kg.b.w) leaving the Carbon tetrachloride control untreated. Results show that induction kidney damage by Carbon tetrachloride increased plasma creatinine, urea, electrolytes, nitric oxide and arginase concentrations but reduced kidney weight and glucose-6- phosphate dehydrogenase activity significantly (p<0.05). Treatment EEPA however significantly reduced creatinine, urea, electrolytes and Arginase concentrations while increasing body weight ( 200mg/kg.b.w) and glucose-6-phosphate dehydrogenase activity. These results indicate that ethanol extract of P.amarus leaves can ameliorate renal dysfunction caused by Carbon tetrachloride.
