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ABSTRACT
present study evaluated the antioxidant properties of methanol extract of the leaves of Justicia carnea in Wistar rat kidneys. Wistar albino rats (n = 36) were assigned to six groups of 6 rats each. Diabetes mellitus was induced in the rats via intraperitoneal injection of 50 mg/kg body weight STZ. Fasting blood glucose (FBG), body weight, acute toxicity and oxidative stress markers were measured. Acute toxicity study showed that at the highest dose of 5000 mg/kg bwt, methanol extract of J. carnea did not produce any mortality in the rats. Graded doses of methanol extract of J. carnea leaves significantly reduced the blood glucose concentration of streptozotocin-induced diabetic rats (p < 0.05). The greatest weight increase was observed in the control group when compared to the other groups (p < 0.05). The plant extract significantly increased the activities of catalase, superoxide dismutase (SOD), and glutathione peroxidase (GPx), but it reduced the concentration of malondialdehyde (MDA) significantly when compared with the diabetic control group (p < 0.05). This study has demonstrated that methanol extract of J. carnea is effective in ameliorating oxidative stress induced by STZ in diabetic Wistar rat kidneys.
