MUSA SAPIENTUM (BANANA) PEEL EXTRACT AMELIORATE RENAL DAMAGE IN WISTAR RATS CO-INDUCED TOXICITY WITH A MIXTURE OF LEAD AND CADMIUM

ABSTRACT

Heavy metals that the body does not need include lead and cadmium. This study looked into the Musa sapientum peels ability to alleviate lead acetate and cadmium chloride co-injury in Waister rats. Five (5) groups of five (5) male rats each were created from the twenty-five (25) male rats. The second group received lead (5 mg/kg) and cadmium (10 mg/kg) twice a week in contrast to the first group, which was fed a regular pellet and water. The fourth and fifth groups were treated with 200mg/kg and 400mg/kg of musa sapientum peels extract, respectively, daily and then given a concentration of lead(5mg/kg) and cadmium(10mg/kg) solution twice a week to induce heavy metal toxicity. The third group received lead, cadmium, and zinc(25mg/kg) twice a week while zinc was given daily. After the animals were killed, the blood and kidney tissue were removed and appropriately prepared for examination on the 29th day. The atomic absorption spectrophotometer was used to determine the concentration of lead and cadmium in blood, faeces and kidney tissue. Using an ultraviolet spectrophotometer, the influence of musa sapientum on kidney biochemical parameters and anti-oxidants parameters was examined. According to the results, the injection of banana extract significantly reduced the levels of lead and cadmium in faeces,kidney tissue and catalase, and increase malondialdehyde in antioxidant parameters . This study concluded that musa sapientum peels extract of 200mg/kg and 400mg/kg musa sapientum peel extract was able to ameliorate and reduce the level of lead and cadmium in the kidney tissue.