ABSTRACT
Using the total protein, total bilirubin, and direct/indirect bilirubin assays, the goal of this study is to determine the modulatory influence of entandrophragma utili on various biochemical markers and histopathology in CCl4-induced liver damage. Traditional medicine has long employed the endemic African genus Entandrophragma (Meliaceae) to cure a variety of ailments. This review covers the pharmacological potential of a wide variety of phytochemicals from the genus Entandrophragma between 1967 and 2018. A comprehensive summary of approximately 166 secondary metabolites, including some semisynthetic derivatives derived from chemical transformations and their biological activities in the medical and agricultural domains, has been provided here based on phytochemical investigations of the genus Entandrophragma. The most intense biological activity are exhibited by limonoids and their progenitor, protolimonoids, which together account for over 69.28% of all secondary metabolites extracted from the genus that have been documented to date. Both types of metabolites combined make up the markers of Entandrophragma.
