Medicinal Plants in the Management of Benign Prostatic Hyperplasia

SUMMARY

This study has discovered and characterized valuable plants that the inhabitants of Ibadan use to treat BPH. It also demonstrates that, even in an urbanized place like Ibadan, there are many different therapeutic herbs, and wisdom regarding their use, method to prepare, and how to be taken. According to the list, 25 plant species from 23 families are helpful in treating the illness. The majority of how recipes are consumed is through oral administration of polyherbal formulations. With the speed at which cities are growing and trees are being cut down, a culture that strives to safeguard these plants and prevent them from going extinct is urgently needed. The plant's preliminary toxicity assessment indicates that an oral intake up to 5000 mg/kg would be safe. Rats given testosterone propionate treatment for 28 days had higher prostatic weight and index, testosterone, DHT, and PSA serum levels, as well as structural distortion of the prostate gland that is indicative of caused BPH. Treatment with different doses of MCA and fractions decreased prostate weight and index, blood levels of PSA, DHT, and testosterone, and also improved the distortion in the prostate's histo-anatomy. In comparison to the 300 and 600 mg/kg doses, the 150 mg/kg dose of the extract was found to be more effective at reversing the testosterone-induced alterations in the MCA-treated rats, also in comparison to the aqueous and chloroform at 300 mg/kg doses, n-hexane and ethylacetate at 300 mg/kg was found to be more effective at reversing the testosterone-induced alterations in the rats.