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ABSTRACT
The liver plays an essential role in the metabolism, detoxification, and homeostasis that takes place in various organs of the body, making its functional status an essential aspect of physiological health. This study investigates the liver function status of Wistar rats administered Alstonia boonei root extract, a medicinal plant widely used in traditional medicine for its anti-inflammatory and antimalarial properties. A total of 9 Wistar rats were divided into control and experimental groups, with the latter receiving varying doses of Alstonia boonei extract over a defined period. Liver function markers, (analytes) including total protein, albumin, and bilirubin levels, were assessed to evaluate liver functionality. The toxicity of the root was also studied on these wistar rats and no result of toxicity was observed. Liver function status indices was also conducted to observe the effect of the root extract on the liver and ascertain the functionality of the liver. The results revealed the increment of total protein (TP) level as the dosage increased weekly,similar trends were observed in albumin (ALB) and globulin (GLB) levels. Total bilirubin (T.BIL) and direct bilirubin (D.BIL) also showed progressive increases with dose and duration of treatment. These findings provide insights into the potential therapeutic or toxicological effects of Alstonia boonei on liver health, contributing to its pharmacological evaluation for safe medicinal use.
