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used to treat a wide range of illnesses, including diabetes, a chronic metabolic disease marked by high blood glucose levels that eventually cause serious damage to the body. This study investigated the lipo-regulatory characteristics of an aqueous polyherbal extract from rats who were induced to become diabetics using Annona muricata, Zingiber officinale, and Andrographis paniculate, diabetes was induced intraperitoneally by injecting streptozotocin into male Sprague Dawley rats. Rats were split into six groups: glibenclamide (positive control), diabetic rats treated with varying dosages of the polyherbal extract, diabetic rats left untreated (negative control), and rats in the normal control group. Samples of blood were taken from the abdominal aortic vein after 28 days. The serum concentrations of high-densitylipoprotein, total triglycerides, and cholesterol weremeasured using standard protocols. Low-density lipo protein and verylow-density lipo protein were compared with low-density lipo proteins usingg enerally acknowledged methods. Ratstreated with the polyherbal extract showed a significant decrease in total cholesterol levels (p≤0.05) as compared to the diabetic rats that did not receive any treatment. Rats administered with the polyherbal extract exhibited a moderate rise in high-density lipoprotein levels and a statistically significant drop in low-densitylipoproteinlevels(p≤0.05)incontrasttothenegativecontrolgroup.Ratswithdiabetes treated significantly reduced their triglyceride levels when compared to those without treatment (p≤0.05). Finally, the polyherbal plant extract showed promise in enhancing lipid profiles in diabeticrats caused by streptozotocin, indicating that it may be used as atherapeutic treatment for managing diabetes-associated dyslipidemia.
