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Diabetes is a chronic metabolic illness characterized by high levels of glucose in the blood which leads over time to serious damage to the body. The effect of diabetes is prominent in the society with the disease having numerous life threatening side effects that is prone to other diseases, making it an immune crippling disorder. Herbal medicine research has been used over the years to curtail certain diseases such as diabetes and it has been proven to yield positive results and maintenance. The aim of this was to evaluate the lipid regulatory property of the bi-herbal aqueous extract on streptozotocin induced diabetes in rats. Wistar rats were selected into six (6) groups (n= 6). Group I (non-diabetic rats) while other groups are diabetic. Anti-diabetic effect of the extract at (50, 100 and 200 mg/kg) and reference group (10 mg/kg glibenclamide) were evaluated using blood glucose estimation, body weight, biochemicals and histopathological study on the study. The Results of the investigation of the lipo regulatory effects of the bi-herbal leaf aqueous extract on diabetic rats exhibited anti-diabetic properties by causing significant reduction in total cholesterol and triglyceride levels when compared with diabetic control across graded doses of the extract (P < 0.05) specifically at higher dose (100 mg/kg). In conclusion, the findings from this study suggest that the tested bi-herbal aqueous extract showed potential Anti-diabetic properties by stimulating insulin secretion and improving insulin sensitivity uptake.
