LEVELS OF TRIMETHOPRIM IN SELECTED FISH POND IN EDO CENTRAL, EDO STATE, NIGERIA

ABSTRACT

Due to the health advantages and relative cost of fish, there has been an increase in aquaculture production, which uses antibiotics to increase productivity and prevent disease. Antibiotic abuse residues found in edible fish pose serious health risk. In this study, Trimethoprim residues were accessed in catfish obtained from 3 aquaculture farms in Edo Central, Edo State, Nigeria. The sampled fish ponds includes; Adedeji fish farm at Igarra camp, Etsako West,Auchi (pond 1), Abubakar fish farm at Audu momoh street, Etsako West, Auchi (pond 2), and Emmanuel fish farm, Location: Iyerekhu, Etsako west, Auchi (pond 3). The detection and quantification of antibiotic residue was carried out using the High performance liquid chromatography (HPLC) technique. The results obtained were compared to the Maximum Residue Level (MRL) recommended for the use of drugs in fish muscle. Trimethoprim was only observed in fish samples from pond 3 with mean levels of 0.75±1.06mg/kg. No Trimethoprim residue was detected from pond 1 and pond 2. The Trimethoprim residues detected was below recommended maximum residue limit (MRL) in fish muscle. The Trimethoprim residue in the fish samples in this study was found to have low risk as the hazard quotients was <1.