Abstract
Post-Exposure Prophylaxis (PEP) is a critical intervention for preventing HIV infection after potential exposure. However, knowledge and perception of PEP among non-healthcare populations, particularly undergraduate students, remain underexplored. This study assesses the knowledge and perception of PEP among undergraduate students residing in the halls of residence at the University of Benin, Edo State, Nigeria. A descriptive cross-sectional design was employed, with a sample size of 297 respondents selected using a multistage sampling technique. Data were collected through structured questionnaires and analyzed using the Statistical Package for Social Sciences (SPSS). Findings revealed that only 38.7% of respondents demonstrated adequate knowledge of PEP, while 33.7% had previously heard of it. 40.4% correctly identified the appropriate time frame for PEP initiation, and 60.6% knew where to access it. Despite this, the overall perception of PEP was positive, with 51.7% of respondents stating they would seek PEP immediately after exposure. Socio-demographic factors such as gender, academic discipline, and socioeconomic background influenced awareness and accessibility. Barriers to PEP utilization included fear of stigma (23.1%), concerns about side effects (47.8%), and limited access to information. Demographically, the majority of respondents were aged 20-25 years (50.5%), female (54.55%), and Christian (90.6%). The study underscores the need for targeted awareness campaigns and integration of PEP education into university health programs. Strengthening health education strategies could enhance knowledge, improve access, and ultimately reduce HIV transmission risk among students. Keywords: HIV, Post Exposure Prophylaxis (PEP), Knowledge, Perception, Undergraduates
