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ABSTRACT
Antimicrobial resistance is a global health issue with particular concern in developing countries, where there are poor antibiotic regulatory policies. Staphylococcus aureus has become a persistent nosocomial and community-acquired pathogen that has become a global menace. This study determined the prevalence and resistance patterns of vancomycin resistant S. aureus isolated from urine samples of healthy students of University of Benin, Ugbowo Campus, Nigeria. One hundred and fifty urine samples of healthy students were cultured and screened for vancomycin resistant S. aureus using standard microbiological protocols and their antibiotic profile susceptibility was investigated using the disc diffusion method according to the Clinical and Laboratory Standards Institute on Mueller Hinton agar. Urine samples were plated on Cysteine Lactose Electrolyte Deficient (CLED) and Mannitol salt agar. Staphylococcus aureus was the second most frequent isolate throughout the sample with 31.25% isolated out of the 150 samples, E. coli (34.54%), Klebsiella pneumonia (22.04%) and Proteus mirabilis (12.17%) were isolated. S. aureus occurred more frequently in female (34.25%) than in male (26.83%). Three (30.6%) S. aureus isolates were observed to be resistant to Vancomycin Multiple Antibiotic Resistant Index of 0.3 and 0.6 were recorded with the highest index recorded against isolate S. aureus 10 (0.6) while the least (0.3) were S. aureus 3 and S. aureus 3. There was a significant difference in the rate of resistance between males and females. It appears that the increasing use of vancomycin in non-complicated infections may contribute to the emergence of S. aureus isolates which turn to be vancomycin-resistant.
