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ABSTRACT
Chromolaena odorata, commonly referred as Siam weed, is a traditional medicinal plant from Asteraceae. It is believed to posses healing potentials for wounds and treatment of pile ailment. Also it has been reported to scientifically possessed antimicrobial activity. Hence, the aim of this study was to determine the antibacterial activity of C. odorata extract against Chromobacterium violaceum, Proteus mirabilis, Staphylococcus aureus,Serratiamarcescens, Klebsiella pneumoniaand Pseudomonas aerogenosa. The leaves were grounded and extraction was carried out using soxhlet method. The antibacterial activity of the extracts was determined using agar well diffusion method at different concentrations (100mg/ml, 50mg/ml and 25mg/ml). The results showed that methanolic extract was able to inhibit the growth of Chromobacterium violaceum, this appeared as zones of inhibition of 17.50mm, 16.50mm and 15.50mm respectively, while the aqueous extract were unable to inhibit the isolates. The antibiotic susceptibility test was done and Chromobacterium violaceum was susceptible to Ofloxacin, Gentamicin and Ciprofloxacin.This study shows that Chromolaena odorata extract possesses antimicrobial activity and thus, represents a promising source for medicines of which when carefully tapped and explored has enormous therapeutic potentials.
