INVESTIGATION OF TOXICOLOGICAL EFFECTS OF GRADED CONCENTRATION OF SUDAN-DYE CONTAMINATED PALM OIL ON BODY WEIGHT, BILIRUBIN LEVELS (TOTAL, DIRECT AND INDIRECT) AND ALPHA FETOPROTEIN GENE EXPRESSION IN VIVO.

ABSTRACT

An increasing amount of research shows how closely nutrition and human health are related. Fat is a necessary macronutrient that is abundant in the human diet and is utilized extensively in the food industry. One example of a vegetable oil is palm oil. The main component of refined palm oil is palmitic acid, a saturated fatty acid. Due to its increased use, particularly in Nigeria, and its nutritional and economic worth, palm oil is becoming more and more expensive. As a result, bulk buyers may be tempted to adulterate it under the false pretense that the quality will be maintained. Therefore, the purpose of this study was to assess how contaminated palm oil affected the albino rats' Non-liver enzyme indicators. For fourteen (14) days, a total of forty-eight (48) rats were utilized in this experiment, split into eight groups of six rats each. The animals were slaughtered at the conclusion of the experiment, and blood samples were taken for biochemical examination. Non-liver marker biochemical indicators were identified. When compared to groups 1 and 2, the non-liver indicators; Total, unconjugated and alpha-fetoprotein while conjugated, all exhibited a substantial increase (p<0.05) and decrease (p>0.05) respectively. A compromise in liver function in rats administered with adulterated palm oil was observed.