You have no items in your shopping cart.
ABSTRACT
Lead induced kidney damage has emerged as a significant concern in terms of human health. This six-week study aimed to explore the renoprotective properties of turmeric (Curcuma longa) extract in countering lead acetate-induced kidney damage in adult male Wistar rats. Twenty-five rats, weighing between 180-200g, were divided into five groups (A, B, C, D, and E), each consisting of five rats. Following a two-week acclimatization period, all rats were provided with standard animal feed (Livestock growers mash) and unlimited access to clean water. Group A served as the control group and received only feed and water. Group B was exposed to 50mg/kg of lead acetate for 14 days before being sacrificed. Group C received 100mg/kg of turmeric extract for 28 days, followed by 50mg/kg of lead acetate for 14 days, before being sacrificed. Group D was exposed to 50mg/kg of lead acetate for 14 days, followed by 100mg/kg of turmeric extract for 28 days, before being sacrificed. Group E received 100mg/kg of turmeric extract for 28 days before sacrifice. Following chloroform inhalation anesthesia, the rats in each group were sacrificed, and their kidneys were harvested and preserved in 10% formal saline for subsequent histological analysis. Histopathological analysis provided compelling evidence of lead acetate induced pyelonephritis in adult male Wistar rats, characterized by tubular necrosis, edema, congestion, and interstitial infiltration of inflammatory cells. The administration of turmeric extract demonstrated its potency as a curative agent, effectively resolving pyelonephritis when applied in a post-treatment regimen.
