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ABSTRACT
Diabetes mellitus is a chronic disease characterized by hyperglycemia and can lead to complications affecting various physiological systems. This study evaluated the potential of a specific bi-herbal formulation- Securidaca longipedunculata and Azanza garckeanea, to improve blood parameters and immune function in a rat model of diabetes. Rats were induced with diabetes using Streptozotocin and divided into six groups of six animals each: Control, diabetic, diabetic treated with bi-herbal formulation and compared with the group of standard diabetes medication (glibenclamide). Hematological parameters (e.g.; red blood cell count, hemoglobin, platelet) were analyzed alongside CD4 and CD8 T Lymphocytes population. The results revealed that treatment with the bi-herbal formulation in diabetic rats improved the hematological parameters and modulated the CD4 and CD8 ratio in a dose-dependent manner. These results suggest that this biherbal formulation might offer beneficial effects in managing diabetes-associated complications and warrant further investigation.
