ABSTRACT
Medicinal plants have long been a major component of both conventional and contemporary medical therapies. Herbal remedies are preferred by many over traditional therapy. This study investigates the impact of Spondias mombin leaf extract on the liver of albino Wistar rats, focusing on body weight, organ weight, and histopathological alterations. The study employed 12 albino rats weighing between 127-g each, divided into four groups of three rats each. Group 1 served as the control, receiving standard feed and water only. Groups 2, 3, and 4 received daily oral gavage of Spondias mombin leaf extract at doses of 100 mg/kg, 200 mg/kg, and 400 mg/kg body weight, respectively, for two weeks. These doses aimed to evaluate effects on the liver assess dose-dependent impacts, and determine toxicity thresholds. The animals were weighed on the 22nd day, and instead of utilizing chloroform anesthesia, cervical dislocation was employed, and the animals were slaughtered by fenestration. The organo-somatic index, starting and final body weights, weight changes, and histological assessment were all completed. Standard error of mean, or mean ± SEM, was used to express the results. One-way analysis of variance (ANOVA) was used to find differences between the means. P values less than 0.05 (p < 0.05) were used to classify values as statistically significant. Variations in the end weight relative to the starting weight in each group Indicate a statistically significant difference between the final and initial body weights (P<0.05). Rats in the control, 100 mg/kg, and 200 mg/kg treatment groups had final body weights that were statistically significantly higher (P<0.05) than the groups' initial body weights. The outcome demonstrated that Spondias mombin leaf extract supplementation did not cause appreciable changes in body weight. The outcome also showed that the liver had inflammatory alterations. However, further studies are warranted to elucidate the underlying mechanisms and assess the negative effect of Spondias mombin leaf extract
