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ABSTRACT
Drought-resistant Icacina tricantha Oliv. (Icacinaceae) is a shrub native to West and Central Africa that is used medicinally by the locals, including the indigenous tribes of Nigeria. The aim of this experiment is to investigate the anti-cataleptic properties of Icacina tricantha and to determine the Biochemical safety profile of Icacina tricantha. Lorke’s method was used to determine the lethal dose 50 (LD50).Behaivioral study was carried out using the haloperidol induced catalepsy. Rats were treated daily with graded doses of the extract (250 -2000mg/kg),after which they were sacrificed ,blood samples collected and used for biochemical analysis. Higher doses (200 mg/kg and 2000 mg/kg) of Icacina tricantha significantly reduced cataleptic score at all frames. Chronic administration of the extract did not alter liver enzymes nor change the level of electrolytes ,urea and creatinine Icacina tricantha reduced catalepsy and did not alter kidney or liver function and thus may be a potential candidate for parkinsonism
