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ABSTRACT
Chromolaena odorata (L.) R.M. King & H.E. Robins (formally called Eupatorium odoratum L.) (Compositae), is one of the tropical plants which is widely used in folklore medicine for treatment of several ailments in Nigeria. The present study was aimed at investigating the in vivo antioxidant status of the hydro-ethanol leaf extract of Chromolaena odorata on Wistar albino rats. A total of 32 rats were grouped into four with each group having eight rats. Group A to C were administered 200, 400 and 800mg/kg bw of the extract respectively, while, Group D served as control. From the analysis of the various results obtained at specific days, there was no significant difference in the malondialdehyde (MDA) level, glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activities when compared to control group. Therefore, the hydro-ethanol extract has no significant effect on the antioxidant activity of glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD).
