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ABSTRACT
This study was carried out to determine the in-vivo antioxidant effects of Greenwayodendron suaveolens leaf extract in rats. Fifteen (15) male albino rats were apportioned into five groups in three replication. Group A (untreated control) received 40 % ethanol given at 1 ml/kg/day p.o. for 7 days, then left for a further 7 days without any intervention. Group B (normal control) were administered 1 ml/kg distilled water orally for 14 days. Group C, D and E were administered with oral doses of 200, 400 and 800 mg/kg/day of the extract respectively for 7 days to a set of rats which had been pre-treated with 40 % ethanol at 1 ml/kg/day for 7 days to induce-oxidative stress. At the end of day 14, blood samples were collected from all animals in each group and analysed for levels of catalase, malondialdehyde (MDA), superoxide dismutase (SOD)and glutathione peroxidase (GTP) activities. The results of the study showed that the group treated with 800 mg/kg of the plant extract had the highest catalase activity (211.64±22.15 μ/mol) while the least activity was observed in the group treated with 200 mg/kg of extract (159.89±0.24 μ/mol). The slight changes were not significantly different (p<0.05) from the control (183.76±17.45 μ/mol). However, the extract at 800 and 400 mg/kg doses significantly reduced (p>0.05) the level of GTP activity. The highest MDA activity was given by the group treated with 800 ml/kg (34.16±7.84 μ/mol), followed by the control group (30.34±0.57 μ/mol), while the least MDA activity was given by the group treated with 200 ml/kg (25.55±0.15 μ/mol). While SOD activity in the cells was shown to be highest in the group treated with 400 ml/kg (7.45±0.97 μ/mol), followed by the untreated group (6.88±0.26 μ/mol), while the least activity was given by the group treated with 200 ml/kg (5.53±0.00 μ/mol) and GTP activity was highest in the control (129.71±0.93 μ/mol), followed by the untreated group (126.45±4.18 μ/mol) while the group treated with 400 ml/kg have the least GTP activity (103.47±0.02 μ/mol)
