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ABSTRACT
Rutin hydrate, a flavonoid found in plants, fruits, and vegetables, is known for its health benefits. Its impact on cardiovascular health is well-studied, but its effects on the non-pregnant rat uterus are less explored. Investigating rutin hydrate’s influence on uterine contractility in rats could provide insights into its potential reproductive health implications. This study was aimed at investigate the effects of Rutin hydrate on the non-pregnant mouse uterus. The study involved non-pregnant albino mice, and isolated uterine tissue strips were mounted in organ baths connected to force transducers. Experiments included assessing Rutin hydrate’s effects on spontaneous uterine contractility, oxytocin-induced contractions, and high KCl induced contractions. Uterine tissue segments were exposed to Rutin hydrate at various concentrations, and the responses were recorded. Additionally, experiments in a calcium-free medium were conducted to examine Rutin hydrate’s impact on uterine contractions without calcium ions. Washout periods and specific timeframes were maintained between administrations. Rutin hydrate exhibited concentration-dependent inhibition of spontaneous uterine contractions, with complete abolition at higher concentrations. It significantly reduced both frequency and amplitude (P-value < 0.05). However, Rutin hydrate showed insignificant inhibition of oxytocin-induced contractions. It had no inhibitory effect on high KCl-induced contractions. While in a calcium-free medium, Rutin hydrate inhibited the amplitude but not the frequency of oxytocin-induced contractions. Rutin hydrate can regulate uterine contractions, but its effects are concentration-dependent. It significantly reduced spontaneous contractions but did not inhibit oxytocin and KCl-induced contractions. Notably, Calcium ions play a crucial role in Rutin's action.
