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ABSTRACTS
The use of medicinal plants has been done since ancient times and may even be considered the origin of modern medicine. Compounds of plant origin have been and still are an important source of compounds for drugs. Result gotten from HPLC analysis was docked with the active sites of the proteins to elucidate the interaction with the compounds, and to also determine the binding affinity and stability. The aim of this study was to investigate the Antidiabetic properties of both the aqueous and ethanol extracts of Ageratum conyzoides, which work through the inhibition of α amylase, α-glucosidase, pancreatic lipase and Receptors for Advanced Glycation Endproducts (RAGE), to see which of the extracts has better inhibitory action. Result gotten from this study, shows that both aqueous and ethanol extracts had the same quantity of phytochemical components (18 compounds). Ethanol extract had better inhibitory potential than the aqueous extract, with Stigmasterol having a docking score of -29.0 kcal/mol for α-glucosidase and Hesperidin with a docking score of -6.283 kcal/mol for RAGE. However, the extracts have higher affinity than Metformin, and slightly higer affinity than Acarbose.Therefore the extracts are better and safer, and can be considered as a therapeutic agent.
