In vitro ANTI-PROTEIN GLYCATION AND ANTIPANCREATIC LIPASE PROPERTIES OF THE AQUEOUS EXTRACT OF Sida acuta

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ABSTRACT

Diabetes mellitus remains a global health challenge with increasing prevalence. Current therapeutic strategies often involve managing hyperglycemia and its complications. Sida acuta, a medicinal plant, has garnered attention for its potential anti-diabetic properties. This study was aimed to analyze the in vitro anti-protein glycation and anti-pancreatic lipase activities of the aqueous extract of Sida acuta. The results demonstrated better inhibition on protein glycation of the aqueous extract of Sida acuta at the lowest concentration of ˂0.78 µg/ml in relation to the standard aminoguanidine 1.96 µg/ml. Similarly on anti-pancreatic lipase activities, the extract also displayed better inhibitory properties of an IC50 value of 2737.06 µg/ml than the standard (Orlistat) which had an IC50 value of 4439.73 µg/ml. These findings show the therapeutic potentials of the aqueous extract of Sida acuta and could be considered a good therapeutic agent for the managements of diseases like diabetes.

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