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ABSTRACT
Asthma is a chronic inflammatory condition affecting the airways, characterized by heightened airway sensitivity and recurrent symptoms triggered by various factors. In the pathophysiology of histamine-induced asthma in guinea pigs, a sensitization phase involves the exposure to allergens like ovalbumin, leading to immune responses dominated by Th2 activity and airway inflammation. Subsequently, during the challenge phase, histamine exposure induces bronchoconstriction, resulting in dyspnea and, in severe cases, convulsions. Evaluation parameters, including pre-convulsion time (PCT), are used to assess interventions. Basophils, akin to eosinophils, can contribute to bronchoconstriction and airway inflammation in certain asthma models. Adansonia digitata, the baobab tree, native to sub-Saharan Africa, has been shown to have protective properties against allergic reactions and the potential to reduce the differentiation of white blood cells responsible for inflammatory mediator release. This study highlights the impact of Adansonia digitata on the levels of basophils in the blood and its potential ameliorative effect of in asthma management
