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Diabetes mellitus is a persistent metabolic disorder characterized by elevated blood glucose levels due to either insufficient insulin production or ineffective utilization of insulin by the body. It remains a global health challenge, causing the exploration of alternative medicine therapeutic interventions. Polyherbal formulations boosts effectiveness while lowering individual herb concentrations, thus minimizing potential side effects. This study investigates the immunoprotective activity of aqueous polyherbal extracts on streptozocin-induced hyperglycemic rats. The polyherbal extracts were administered orally to the hyperglycemic rats, and their effects on immunoprotection were assessed. Rats were divided into groups and were administered with streptozocin (50 mg/kg), Glibenclamide (10 mg/kg) and polyherbal extract at various graded dose (50, 100, and 200 mg/kg). CD4 and CD8 counts were measured to assess immune response. The results showed at Glibenclamide and PAE at all dose significantly increase the CD4 counts compared to the streptozocin induced diabetic rats (p < 0.05). Moreover, PAE at all doses demonstrated a significant increase in CD8 counts compared to the streptozocin induced diabetic rats (p < 0.05). The study sheds light on the mechanisms underlying the immunoprotective effects of the polyherbal extracts and it demonstrated significant immunomodulatory effects of the polyherbal aqueous extract in diabetic rats, highlighting it's therapeutic potentials in the management of diabetes-related immune dysfunction. Hence, the dose of the polyherbal extract showed no adverse effects.
