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ABSTRACT
Modern scientific research has revealed that ginger possesses numerous therapeutic properties including antibiotic, antimicrobial, antioxidant, and ability to inhibit the formation of inflammatory compounds, and direct anti-inflammatory effects. Zingiber officinale is a flowering plant whose rhizome is widely used as a spice and folk medicine. This study is to investigate the histomorphological effects of ginger on the ovary, uterus and reproductive parameters of adult female Wistar rats. Twenty-five adult Wistar rats were employed for this study. The rats were randomly selected into five groups (n=5) with Group A as the control group which was fed with normal rat chow and water ad libitum. Group B was fed with normal rat chow and water ad libitum orally and were mated to litter. Group C was mated and administered 50mg/kg body weight of Zingiber officinale orally for 19 days before sacrifice. Group D was administered 50mg/kg body weight of Zingiber officinale orally and were mated to litter. Group E was administered 50mg/kg body weight of Zingiber officinale orally and were unmated. At the end of the experiment, the animals were sacrificed under chloroform anesthesia and their organs were harvested and taken to the histology laboratory for processing. Data were subjected to statistical analysis using the IBM SPSS statistics software (Statistical Package for Social Science) (Version 25) and relevant statistical values were obtained. One-way analysis of variance (ANOVA) and the paired students T-tests was carried out where appropriate and data were presented as mean ± SEM. Data revealed there were significant difference (P<0.05) of body weight in all the groups, when the initial body weights were compared to the final body weight. The mated ginger treated experimental group had no significant difference (p>0.05) in number of litters compared to untreated. The histological slides showed the ovary had no significant change in number of follicles in the ovary between the ginger treated and the control but there was obvious evidence of dilatation of blood vessels in ginger and unmated compared to control. There was no significant difference in gonadosomatic index across the groups. The histology of the uterus revealed that there was no presence of resorption and implantation.
