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ABSTRACT
This study was aimed at accessing the serum lipid level and the histopathological examination of the hearts of male Wistar rats. This research investigated the biochemical effects of the methanol extract of the stem of Anthocleista djalonensis on the heart status of paroxetine-induced sexual dysfunction in male Wistar rats. 575g of powdered stem of Anthocleista djalonensis was dissolved in 4L of methanol and was left for 72 hours with regular stirring, it was then filtered, evaporated and further dried with an oven. Sexual dysfunction was induced in rats with Paroxetine, 100 mg/kg and 200 mg/kg of methanol extract and 80 mg/kg of Tadalafil drug was administered to the sexually dysfunctional rats. 25 male Wistar rats were divided into five groups labelled A, D, E, F, G. Group A was control and Group D to G were induced with sexual dysfunction using paroxetine for seven days. Thereafter, Group D and E were treated with methanol extract of Anthocleista djalonensis and Group F was treated with Tadalafil for twenty-one days. Group G was untreated. After 21 days, the rats were sacrificed and the hearts were harvested, homogenized and centrifuged, they were packed into EDTA bottles and refrigerated. The following assays were carried out; LDL, HDL, Cholesterol, SOD and MDA. The activity and concentration of these assays were determined using standard techniques. The results were statistically analyzed using ANOVA. The results showed that paroxetine caused a significant increase in SOD, HDL, and Cholesterol concentration levels (p<0.05) and a significant decrease in MDA levels (p<0.05). The results also showed that the methanolic stem extract of Anthocleista djalonensis had a protective effect against Paroxetine-induced sexual dysfunction. It showed that 200 mg/kg B.Wt of extract is able to lower cholesterol and MDA levels. The histopathological examination of the heart of Wistar rats showed that there was no damage to the organ.
