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ABSTRACT
Liver cirrhosis induced by carbon tetrachloride is perhaps the best-studied model of liver cirrhosis (Cornelius, 1993).The prevention of carbon tetrachloride-induced elevation of plasma aspartate and alanine transaminases and alkaline phosphatase activities, and plasma bilirubin level, in animals pretreated with the aqueous extract of the leaves of Acalypha wilkesiana shows its ability to protect normal functional status of the poisoned liver, in addition to protecting against subsequent lead acetate hepatotoxicity. The mechanism by which the extract produces its hepatoprotective activity is not certain. However, it is possible that β-sitosterol, a constituent of the extract of the leaves of Acalypha wilkesiana (Ikewuchi et al., 201) is at least partly responsible for the protective activity against lead acetate hepatotoxicity. Earlier, Lin and Tome (988) had reported that β-sitosterol was the anti-hepatotoxic principle in Sambucus formosana.
