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ABSTRACT
Juglans regia Linn is a versatile tree species renowned for its economic, nutritional, and medicinal value. Methotrexate is a widely used and multifunctional medication, commonly used as antirheumatic drug, causing hepatotoxicity at higher doses. The aim of this study was to investigate the effect and any potential benefit of Juglans regia Linn in the liver and lungs tissue of wistar albino rats pretreated with methotrexate. A study design was employed by grouping 25 wistar albino rats into 5 groups (control, negative, positive and counter groups). Hepatic biomarkers (AST, ALP, ALT, CB, TP, Albumin and Globulin) and histopathological changes were evaluated. SPSS version 20 (statistical programme for social sciences) was used analyse the generated data. The biomarkers showed no significant difference between the different groups at p<0.05. In histopathological findings, methotrexate was found to have an inflammatory effect on the lungs tissue of the experimental animals in group B and slight structural changes in the liver tissue of the same group. Group A and C presented no effect on the hepatic and pulmonary tissue. However, in the liver tissue of group D slight structural changes were observed. In group E, there were no effect on the lungs and liver tissues, suggesting that at higher doses the extract was able to counter the effect of the drug. In conclusion this study suggests that Juglan regia Linn possesses protective qualities against methotrexate-induced liver and lungs damage in wistar albino rats. More research is needed to acquire a better understanding of the mechanism of action of Juglans regia Linn against methotrexate.
