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ABSTRACT
Traditional medicinal herb consumption is very high in Nigeria because it is accessible and not usually expensive. In recent years, there has been an astronomical rise in the use of medicinal plants (Ahmed., 2017). Substance abuse is a major health related problem in Nigeria. The liver is the major target of toxicity in the body and a loss of liver function is fatal and can cause death. Hence, this study is aimed at investigating Changes in the weight of the organ, Changes in level of liver enzymes of treated groups and histological changes in the liver of the adult Wistar rats across all groups of experimental animals. The animals used were 25 adult Wistar rats divided into 5 groups which are: group A (control), group B (cobalt only), group C (low dose of the extract + cobalt), group D (agaricus sylvaticus only) and group E (high dose of the extract + cobalt). The duration of the study was 30 days and the right dose of the extract administered daily for 30days. The control was given no extract. The dose administered to group B was xviii 25mg/kg of cobalt only while groups C, and E were given 300mg/kg, and 600mg/kg both with 25mg/kg of cobalt. Group D was given 300mg/kg of the extract only. From the results, by comparing only initial and final body weights, there was significant difference in all the groups when compared to control. Considering hepatic weight, there was significant difference noticed from the control group. For liver enzyme results, there was significant difference noticed in the control group; there was a statistically significant increase (p>0.05) of total alkaline phosphate level in group that received 25mg/kg of cobalt for 14 days when compared to control. Regarding alanine transferase, however, there was significant difference. Also, in aspartase transferase there was a significant drop in all groups when compared to control. In the total protein, total bilirubin and albumin levels, significant difference was noticed while in the conjugate bilirubine and globulin levels there was no significant difference.
