HEMATOLOGICAL PARAMETERS AND ANTIOXIDANT CAPACITY OF THE HEART OF WISTAR RATS TREATED WITH ETHANOL EXTRACT OF Funtumia elsatica

ABSTRACT

This study aimed to investigate the effects of Funtumia elastica extract on hematological parameters and antioxidant capacity in Wistar rats. Male Wistar rats were divided into four groups and administered varying doses of Funtumia elastica extract (200 mg/kg bw, 500 mg/kg bw, and 1000 mg/kg bw) for a specified duration. Hematological parameters, including white blood cell count (WBC), red blood cell count (RBC), and lymphocyte counts (LYM#), were assessed using standard laboratory techniques. Additionally, hepatic and renal antioxidant markers, including malondialdehyde (MDA), glutathione peroxidase (GPx), catalase, and superoxide dismutase (SOD), were measured to evaluate antioxidant capacity. The administration of Funtumia elastica extract did not significantly alter most hematological parameters compared to the control group. However, significant changes in lymphocyte counts and red cell parameters were observed, suggesting potential immunomodulatory and erythropoietic effects. Furthermore, Funtumia elastica extract exhibited antioxidant properties, as evidenced by reductions in hepatic MDA levels and modulation of renal antioxidant enzyme activity. Funtumia elastica extract demonstrates potential therapeutic effects on hematological parameters and antioxidant capacity in Wistar rats. These findings highlight its potential utility in the management of hematological disorders and oxidative stress-related diseases. Further research is warranted to elucidate the underlying mechanisms and clinical implications of Funtumia elastica extract in human subjects.