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ABSTRACT
The co-infection of malaria parasites and helminths is common in the tropics. Their pathogenicity lies in the infectivity of parasites and their modulation of the host immune system. This study aimed to generate epidemiological data of malaria and helminths in apparently healthy humans in a rural population in Bayelsa State; determine the serum concentration of Interleukin-4, Interferon-gamma -IFN-γ, Macrophage Inflammatory protein-MIP-β/CCL-4 and Eotaxin-3 /CCL 26 in healthy volunteers infected with malaria and helminths and their values after treatment.
Two sets of data; malaria and helminths were generated from school and community based study, carried out between May 2016 and July 2018 in four rural communities- Otuegela, Immiringi, Otuesega and Ibelebiri in which there was ongoing mass deworming and anti-malaria administration. Ethical approval was obtained from the Ethical Committee, College of Medicine, University of Benin, Nigeria (CMS/REC/2017/016). From every participant, blood and stool samples were collected; from 1441 volunteers, age-range 4 – 80 years. Diagnosis of helminths, malaria parasites were by standard procedures. The body mass index (BMI) of children was determined. Measurement of haemoglobin concentration and blood cells was automated (ABX Micros 60). Infected volunteers were treated specifically and after 18 days the second round of blood and stool samples were collected from treated participants only and analyzed. Immune molecules were measured by ELISA (PeproTech, USA) protocols. Data were analysed with the "R" Programme (version 2016) and a P-value of < 0.001 was considered significant.
