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ABSTRACT
This study investigates at the possible haematotoxicity of an ethanol extract obtained from Phyllanthus amarus leaves and the accompanying histological changes in the tissues of rats exposed to carbon tetrachloride (CCl4). Phyllanthus amarus, a medicinal plant known for its numerous therapeutic effects, has sparked interest in traditional medicine due to its potential hepatoprotective and antioxidant capabilities. Male rats were divided into groups and given either Phyllanthus amarus extract, CCl4, a mixture of both substances, or served as a control. Haematological indicators such as complete blood counts (CBC), serum markers of liver function, and oxidative stress markers were thoroughly examined. Microscopy was also used to undertake histological tests on liver, kidney, and cardiac tissues. This study emphasizes the haematoprotective potential of Phyllanthus amarus leaves and emphasizes the need for more research to explain the underlying mechanisms of action. The findings suggest that Phyllanthus amarus might be a potential natural resource for designing therapies to reduce haematotoxicity caused by chemical exposure. Such discoveries might have farreaching repercussions for human health and pharmacological applications.
