HAEMATOLOGICAL PARAMETERS AND PLASMA IN THE LUTEAL AND MENSTRUAL PHASE AMONGST YOUNG FEMALE ADULTS

ABSTRACT

Menstruation is a phenomenon unique to females and nearly universal experience in women's lives but is pooly understood. It is characterized by co-ordinated sequence of hormonal change however, whether these changes affect haematological parameters and plasma fibrinogen concentration is not known. The present study was undertaken with the aim to determine the influence of menstrual cycle on haematological parameters and plasma fibrinogen concentration among young female adults by studying the luteal and menstrual phases. A total of 100 healthy females where followed up in their monthly circle. They were aged 18 to 28 years and meet the inclusion criteria. Under aseptic condition, 200 blood samples were collected comprising of 100 luteal phase and 100 menstrual phase and immediately screened for haematological parameters using an automatic multi parameter blood cell counter (sysmex KX–21) and fibrinogen concentration by dry clot method. The data obtained were subjected to statistical analysis using independent sample t-test and ANOVA. Red blood cell count, Haemoglobin, Packed cell volume, mean cell volume and mean cell haemoglobin show no significant difference in the luteal phase compared to the menstrual phase. Lymphocytes, MID, Granulocyte count showed a significant increase in the luteal phase compared with menstrual phase. Fibrinogen concentration showed a significant increase in the luteal phase compared with the menstrual phase. In conclusion, there is cyclic changes in lymphocytes count, granulocytes count, platelets count and fibrinogen concentration which could be due to phasic changes in female sex steroids, endometrial shedding & blood loss, inflammatory like process during ovulation and shifting of immune response from type 1 to type 2 during the luteal phase.