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Aquatic ecosystems and the health of aquatic organisms may be significantly threatened by environmental contamination brought on by industrial activity. In this study, a commonly found freshwater catfish called Clarias gariepinus, was used to examine the genotoxic effects of effluents emitted from a ceramic manufacturing company on its liver and gills. Effluents from ceramic manufacturing company often contain various chemical pollutants including heavy metals, which have the potential to cause genotoxicity in aquatic organisms. In this study, Clarias gariepinus were subjected to a 96-hour acute toxicity test in which they were exposed to various effluent quantities. It was observed during exposure that the fish placed in the media devoid of ceramic effluents (Control) survived the 96 hour exposure period and exhibited normal fish behaviour, while in the other concentrations, restless behaviour, erratic movements and fish bringing out bubbles from their mouth was observed. Genotoxicity assessment was performed using comet assay to detect possible genetic damage on the liver and gills of Clarias gariepinus. During the course of analysis, 0.001 was calculated as the standard mean value. The P indicated the level of damage done between the concentrations. The results indicated that exposure to ceramic effluent had a high significant (p=<0.0001) adverse effects on the liver and gills of Clarias gariepinus. Both organs experienced same level of damage.