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ABSTRACT
Aspirin is being used as an effective analgesic and anti-inflammatory agent at doses >325mg daily. At low doses (75-325mg daily), aspirin is the key antiplatelet drug in the pharmacology prevention of cardiovascular diseases. Systemic effects of aspirin in the gastrointestinal mucosa are associated with mucosal damage in the upper and lower gastrointestinal tract. The risk of upper gastrointestinal bleeding with aspirin is increased with old age, male sex, ulcer history and concomitant medication with NSAIDS, cyclooxygenase 2 selective inhibitors, corticosteroids or other antithrombotic agents. Eradication of Helicobacter pylori infection might be an additional option in patients with a history of ulcer. Gastric ulcer are common and serious disease in the world. This study evaluated the effects of the methanol extract of Spondias mombin (stem bark) in aspirin induced ulcerated rats. Twenty-five adult male Wistar rats were randomly divided into five groups of five rats each. Methanol extract of Spondias mombin(250 and 500 mg/kg BW) and misoprostol, a standard drug (30mg/kg) was administered orally for 7 days to act as a gastro protective agent prior to the induction with aspirin(300mg/kg BW). At the end of the experiment, ulcer index, gastric secretions and antioxidant parameters were evaluated. The extract showed a significant (p<0.05) anti-secretory and gastric cyto-protection and due to acid inhibition. There was significant increase of the gastric volume, pH, acidity and ulcer index of animals induced with aspirin without the treatment. Based on this study it will be concluded that the methanol extract of spondias mombim showed a positive effect against ulcer induction by aspirin.
