FORMULATION OF CONTROLLED RELEASE MATRIX TABLET OF IBUPROFEN

ABSTRACT

Background; According to the British pharmacopoeia: tablets are solid dosage formulations containing a unit dose of one or more active ingredients and is obtained by compressing uniform volumes of particles Objective: The purpose of the study is to evaluate the effect of Eudragit and Pectin as polymers in the formulation of controlled release matrix tablet of Ibuprofen Method; Different tablet batch formulations were prepared by direct compression method. The active drug (Ibuprofen) and polymer (Eudragit) were mixed well for 10 min in a mortar and pestle. To this blend, a calculated amount of diluent (lactose) was added and mixed thoroughly for 5 minutes after which a calculated amount of magnesium stearate and starch were added and mixed thoroughly before being directly compressed into tablets using a single punch rotary tablet machine of 10 mm diameter. The procedure was then repeated using Pectin in place of Eudragit. Results: The formulation containing Eudragit L-100 were less compact and the tendency to undergo friability was higher when compared to pectin. Also, there exists variations in disintegration times. However, the rate of dissolution exhibited by both formulations showed a sustained release of the drug produced with both binders over an extended time frame. A curve of mean absorbance versus concentration was plotted with a correlation co-efficient of 0.9975. In both binders, the binding ability increases with increase in concentration. Conclusion; from the results obtained from the experiment a controlled release matrix tablet of Ibuprofen is a better system for a twice daily dosage regimen of the drug which therefore improves patient adherence and compliance to drug administration and therapy.