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Abstract
In this study, the effect of aqueous methanol extract of Geophila obvallata (GEO) leaf on carbon tetrachloride-induced changes in plasma lipid profile was investigated. A total of thirty albino wistar rats divided into six group consisting of five rats each were used for the experiment. All animal were allowed unlimited access to feed and water. In addition animals in groups 3, 4 and 5 were pre-treated with aqueous methanol extract of Geophila obvallata leaf at the respective doses of 50, 100 and 150mg/kg body weight for 14 days. Animals in groups 2 were given oral administration of carbon tetrachloride (CCl4) at a dose of 1:1 ratio of CCl4 and olive oil. Animals in groups 6 were given normal feed and aqueous methanol extract of Geophila obvallata (GEO) leaf at dose 100mg/kg body weight for the same 14day. All animals were sacrificed on day 15 and their plasma lipid profile was analysed. Result obtained indicates that treatment with carbon tetrachloride (CCl4) resulted in a significant increase in the plasma total cholesterol and LDL-Cholesterol levels while the HDL-Cholesterol levels were decreased significantly. Pre-treatment with aqueous methanol extract of Geophila obvallata (GEO) leaf provided varying degree of amelioration as seen in the significant (p<0.05) reduction in the cholesterol and LDL-Cholesterol levels in a dose dependent manner. The extract was also found to have high antioxidant properties such as tannins, phenolics, flavonoids. This phytochemicals exert its activity by inhibiting free radicals mediated damage to hepatocyte and the subsequent alteration in lipid metabolism.
