ABSTRACT
Alstonia boonei commonly known as stool wood is a specie plant in the apocynaceae family. A. boonei plant is used for treatment of malaria, as an antimicrobial, antidiabetic, aphrodisial and antipyretic activities. The bark has been found to possess antirheumatic, anti inflammatory, analgesic/pain-killing, antipyretic, properties. Proximate analysis, acute toxicity and anxiolytic study of A. Boonei was carried out in this study.The Proximate analysis reveals 9.4%, 3.2%, 46.4%, 11.3%, and 29.7% for moisture content, crude fat, crude fibre, ash content, carbohydrate respectively. In the acute toxicity study,dosage of 10mg/kg, 100mg/kg, 1000mg/kg of ethyl acetate extract of A. Boonei stem bark was administered orally to swiss albino mice.No death of mice was recorded.And LD50 value greater than 5000mg/kg was obtained which showed A.Boonei is non-toxic using the Hodge and sterner toxicity scale. The anxiolytic study was carried out using standard established procedure and reveals antianxiety activity.
