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ABSTRACT
This work focuses on the extraction, characterization and determination of anxiolytic activity methanol extract of Datura metel (purple thornapple) in balb/c mice using hole board test model. Extraction was carried out with the use of a Soxhlet extactor using methanol as the extraction solvent. Percentage yield of the extract was 19.22%. Phytochemical screening of the extract indicated the presence of glycosides, alkaloids, eugenols and flavonoids. Saponins and terpenoids were largely present. Thin layer chromatography (TLC) analysis showed that methanol had the highest retention factor when compared with other solvents, hence making it the most suitable for this extraction process. Characterization was carried out with High Performance Liquid Chromatography (HPLC). Results of this analysis indicated an abundance of some important constituents namely; Scopolamine, Atropine, Quercin and Beta-caryophyllene, with Scopolamine being the most abundance, hole board test was carried out to show that the extract can help in the treatment of anxiety.
