Abstract
Background: Chitin is a biopolymer that is widely found in fungal cell walls. Because of its biocompatibility, biodegradability, non-toxicity , Disintegration and Binding Properties, chitin has potential uses in a number of Pharmaceutical industries and medicine.
Purpose: This study aims to characterize chitin obtained from Pleurotus Tuber-Regium.
Method: Demineralization, Deproteinization, And Precipitation were the sequential procedures used to remove chitin from Pleurotus tuber-regium. In order to assess the purity, structure, morphology, and thermal stability of the extracted chitin, thermal analysis methods such as Differential Scanning Calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) were employed. The extracted chitin was added to paracetamol tablets, and its impact on the physicochemical characteristics of the tablets—such as their disintegration time, hardness, stability, and dissolution profile—was evaluated.
Results: This finding proved the efficient extraction of chitin from Pleurotus tuber-regium, which was identified by its distinctive FTIR peaks and DSC thermal characteristics. The addition of chitin to paracetamol tablets showed results in terms of Tablet hardness ranging from 5.34±1.23kg – 8.80±05kg, Disintegration time ranging from 20.32±1.33secs – 48.24±1.10secs, and dissolution profile ranging from at 5mins: 43.65% - 65.45% to 45mins: 91.55% - 102.20% .
Conclusion: This work shows that chitin from Pleurotus tuber-regium has the potential to be a useful excipient in the formulation of tablets, providing the creation of innovative pharmaceutical products with improved biocompatibility and performance.
