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ABSTRACT
In many countries around the world, extracts from different morphological parts of Annona muricata Linn. (Annonaceae) are commonly used medicinally for the management, control, and/or treatment of a wide range of human illnesses, including diabetes mellitus (DM). The goal of the current study was to look into any potential anti-toxin properties of A. muricata leaf methanol extract (AME) in bromate-induced toxicity. The used animals were The rats were placed into six experimental groups, each of which had seven rats. Rats in Group A served as the "control" group, receiving intraperitoneally administered doses of distilled water equivalent to the volumes of AME and reference drug solutions. In contrast, Groups 2, 3, 4, 5, and 6 received intraperitoneally administered doses of bromate that were either left untreated or treated with silymaria or a high dose of the extract. Hepatic tissues were removed following euthanasia and biochemically analyzed to detect the antioxidant enzyme catalase (CAT). The CAT activity was likewise significantly reduced (p 0.05) by bromate therapy. Serum insulin levels and antioxidant enzyme activities were considerably (p0.05) elevated by AME therapy. The results of this investigation on laboratory animals indicate that A. muricata extract protects and benefits hepatic tissues that have been subjected to oxidative stress caused by bromate, presumably by reducing lipid peroxidation and subtly increasing production of endogenous antioxidants.
