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ABSTRACT
Malaria is the one of major diseases which threatens people’s life in Africa. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for are cent increase in malaria – related mortality, particularly in Africa. Artemisinin – derivative combinations are particularly effective, since they act rapidly and are well tolerated and highly effective.
Wide spread use of these drugs could roll back malaria. The aim of this study was determine the rate of Artequick and Pepariquine Resistance in Benin Metropolis. Patients who had cases of artequick resistance and met the inclusion criteria were recruited for the study. The blood samples of these patients were collected for Malaria parasite test and Full blood count analysis. Patients were then placed on quinine infusion for some number of days and their blood samples were collected upon completion of quinine treatment to determine their MP and FBC status. The result showed that there was significant difference in pack cell volume (PCV) and white blood cell (WBC) of the patients before treatment with quinine when compared to control, whereas after treatment there was no significant difference in the MP and FBC status when compared to the control group, indicating that there was an improvement after the treatment. Conclusively this study points to the fact that there could be an emerging resistance to artequick medication in this part of the country. Hence more studies are to be conducted to ensure that the current regimen are optimal in order to avoid the development and spread of multi drug resistance strain in the future.
