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ABSTRACT
The ameliorative effect of justicia carnea on blood glucose level and lipid profile in Streptozotocin-induced diabetic albino rats was evaluated. Recent research has proven that plants are preferably used in treatment of chronic diseases than prescribed drugs. Diabetes is a raging disease especially in countries like Nigeria and as a matter of fact very chronic and deadly. This research was carried out using a total of (48) rats. This research started with the extraction of the plant using methanol. Acute toxicity study was carried out using a total of (12) rats at different dosage of 10mg/kg, 100mg/kg and 1000mg/kg respectively for low dose and high doses of the extract at 1600mg/kg, 2900mg/kg and 5000mg/kg. No mortality ratio was recorded. The research continued using a total of (36) wistar rats were grouped into six groups of six rats, each weighing between 150-200g. They were acclimatized for 21 days after which, Diabetes was induced by intraperitoneal injection of 50mg/kg of Streptozotocin. Group 1 was used as the control group, group 2 were the diabetic rats but untreated, group 3 includes diabetic rats administered with metformin, group 4 includes diabetic rats administered with 100mg of the methanol extract of justicia carnea, group 5 includes diabetic rats administered with 200mg of the methanol extract of justicia carnea and group 6 involved the diabetic rats administered with 500mg of methanol extract of justicia carnea. The pilot of this study resolved a significant p< 0.05 decrease in blood glucose when compared to untreated diabetic rat. A significant p<0.05 decrease in LDL, cholesterol and Triglycerides when compared to the untreated diabetic rat and a non-significant increase in HDL depending on the dose of the extract administered. The result of this study showed that methanol leaves extract of justicia carnea exhibited anti-diabetic effects against Streptozotocin induced diabetic rats in a dose dependent manner and can be used to prevent health conditions associated with the condition.
