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ABSTRACT Background: Azadirachta indica is one of two species in the genus Azadirachta that is frequently used for its wound healing, anti-diabetic, anti-malaria and anti-inflammatory properties. Aim: This study is aimed to evaluate the effect of the ethanol extract Azadirachta indica of the stem bark of plant on monosodium glutamate (MSG) induced fibroid in female wistar rats. Method: Acute and toxicity studies were done using Lorke’s method. Curative studies (measuring total plasma cholesterol, plasma protein, plasma estradiol and plasma progesterone) using 100mg/kg, 200mg/kg and 400mg/kg doses of Azadirachta indica stem bark extract on 400mg/kg monosodium glutamate-induced uterine leiomyoma in female wistar rats was conducted. Histology studies and biochemical assays were carried out on the uteri and blood samples respectively. Results: Administration MSG to the rats elevated significantly (P ≤ 0.001) cholesterol. Curative treatment significantly reduced (P < 0.05) the elevated plasma cholesterol but did not significantly reduce (P > 0.05) plasma protein, estradiol and progesterone treatment. The lethal dose was 5000 mg/kg administered orally. Conclusion: The ethanol extract of Azadirachta indica did not cure the uterine fibriod induced in uterus by the monosodium glutamate.
