EVALUATION OF THE ANALGESIC ACTIVITIES OF THE METHANOL LEAF EXTRACT OF ANTHOCLEISTA GRANDIFLORA ON ALBINO MICE

  ABSTRACT

 This study was aimed at evaluating the analgesic effect of methanol extract of the leaves of Anthocleista grandiflora in mice using two pharmacological models Vis; Acetic-acid induced abdominal writhes and formalin induced pain in mice. The study was motivated by need to investigate the folklore use of the Anthocleista grandiflora in the treatment of pain, wound, and diseases with significant inflammatory component. Forty animals (mice) were used for this study and were grouped into five groups of four mice each. The results of the study showed that the extract have significant (p<0.05) analgesic effect at dose range of 100 to 400 mg/kg in mice in the acetic acid induced writhes. Significant (p<0.05) analgesic effect was observed at 100 and 400 mg/kg in formalin induced pain in rats. This study thus provides scientific information and validates the ethnobotanical use of A. grandifloraleaves in disease management. The findings of this study also reveal that potentially A. grandifloracould be a source of pharmacologically active compounds of pharmaceutical importance.