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ABSTRACT
Cervical cancer is a cancer that originates from the cervix, the part of the womb (uterus) that opens into the vagina. Globally, it is the second commonest cancer in women after breast cancer. It is caused by human papilloma virus (HPV) a sexually transmittable virus. The aim of this study was to evaluate some haemostatic and haematological parameters among 130 histologically confirmed cervical cancer patients attending Gynecology/Oncology clinics of Ahmadu Bello University Teaching Hospital Zaria, and to compare them with 130 apparently healthy women as control subjects. Samples were collected and analyzed using standard techniques for prothrombin time (PT), activated partial thromboplastin time(APTT) and plasma fibrinogen time (PFT). The PT (P<0.001) and APTT (P=0.002) were significantly higher in patients with cervical cancer than controls. No significant difference was observed in fibrinogen values in both test and control subjects (p=0.076). Haemoglobin concentration (HB), packed cell volume (PCV), mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) were significantly lower (P<0.0001) in patients with cervical cancer than control subjects. On the other hand, white blood cell count (WBC) (P<0.0001), neutrophil(P<0.002), monocyte(P<0.0001) and platelet (P<0.0001) were significantly higher in patients with cervical cancer than controls, while lymphocyte value in both test and controls was not significantly different (P=0.095). Neutrophil-lymphocyte ratio (NLR) was significantly higher (P<0.001) when compared with control subjects. A negative correlation was observed between mean cell volume (MCV) and activated partial thromboplastin test (APTT), (r -0.237)(p=0.007). Also, there was a positive correlation between mean cell volume (MCV) and plasma fibrinogen test (PFT), (r= 0.271)(p=0.002). Age group distribution shows that ages 41-50years has the highest frequency/percentage both in test 57(44.2%) and control 64(49.2%) respectively, followed closely by ages 51-60years.This study has revealed some of the commonly affected haemostatic and haematological parameters in cervical cancer patients and has also revealed a decline in age group of affected women.
