You have no items in your shopping cart.
This study aimed to assess the antidepressant effects of methanol seed extract from Hunteria umbellata using the forced swim test in mice. The seeds were collected, dried, powdered, and then extracted with methanol using a Soxhlet apparatus. Twenty mice of varying sexes, weighing between 18 and 22.5 grams, were randomly divided into five groups, each consisting of four mice. Group I received distilled water (as a vehicle for the extract), while groups II, III, and IV were treated with 250, 500, and 1000 mg/kg of the extract, respectively. Group V, serving as the standard group, received 25 mg/kg of Imipramine. Mobility and immobility durations were observed during the last 4 minutes of a total 6-minute period in all groups, and results were expressed as mean ± standard error of the mean. Statistical analysis was performed using one-way analysis of variance with Graph Pad Prism version 6.0. The study results indicated that the plant extract did not significantly reduce the duration of mobility and immobility time (measured in seconds) in the forced swim test. However, the decrease in immobility suggests that the extract possesses some level of antidepressant activity.
